Opportunity Information: Apply for PAR 25 218
The National Institutes of Health (NIH) is offering a grant opportunity called "Research Infrastructure Development for Interdisciplinary Aging Studies (R61/R33 - Clinical Trial Optional)" under funding opportunity number PAR-25-218. The goal is to build new, sustainable research infrastructure that can move aging science forward in areas where progress depends on interdisciplinary partnerships and collaboration. Rather than funding a single standalone research study, this program is centered on creating shared capacity such as platforms, resources, networks, methods, tools, data systems, coordinated teams, or other infrastructure that enables multiple projects to tackle key aging-related questions that sit at the intersections of different fields.
The award uses the NIH Phased Innovation Award mechanism (R61/R33), which is designed to support ideas that need an initial development stage before scaling up. The first phase is the R61, providing up to two years for early developmental activities. This is where applicants would typically build, test, and refine the core components of the proposed infrastructure, demonstrate feasibility, establish partnerships, and meet clearly defined milestones that show the infrastructure is working as intended. If the R61 phase meets its objectives, the project can transition into the second phase, the R33, which can provide up to three additional years to expand and fully implement the infrastructure. The R33 phase is meant for broader rollout, growth in use and reach, and strengthening the infrastructure so it can support multiple interdisciplinary aging projects over time. A central emphasis across both phases is sustainability, meaning the infrastructure should be designed to persist and remain useful beyond the grant period, rather than being a short-lived resource tied to one project team.
Clinical trials are optional, which means applicants may include a clinical trial component if it is appropriate for developing or validating the infrastructure, but they are not required to do so. The activity category is Health, and the opportunity is classified as a discretionary grant program. The CFDA numbers associated with this opportunity are 93.313 and 93.866. The application closing date listed is 2025-12-02, and the opportunity was created on 2024-11-07. The notice does not provide a specific award ceiling or expected number of awards in the provided text, so applicants would need to consult the full NOFO and NIH budget guidance for details on allowable budgets, milestones, and transition criteria.
Eligibility is broad and includes many types of domestic U.S. organizations and governmental entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized governments); public housing authorities and Indian housing authorities; nonprofit organizations with and without 501(c)(3) status (outside of higher education); for-profit organizations other than small businesses; and small businesses. The NOFO also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions.
At the same time, there are important restrictions related to non-U.S. participation. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization. Non-domestic components of U.S. organizations are also not eligible to apply. However, "foreign components" are allowed as defined by the NIH Grants Policy Statement, meaning a U.S.-based applicant can include certain allowable foreign activities or collaborations when they meet NIH policy requirements and are justified as necessary for the project. This structure allows international collaboration in a limited, policy-governed way, while keeping the applicant organization itself domestic.
Overall, this program is aimed at teams that can bring together multiple disciplines to create enabling infrastructure for aging research, with a clear developmental plan in the R61 phase, a credible scaling plan in the R33 phase, and a realistic strategy for long-term sustainability and impact.Apply for PAR 25 218
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research Infrastructure Development for Interdisciplinary Aging Studies (R61/R33 - Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.313, 93.866.
- This funding opportunity was created on 2024-11-07.
- Applicants must submit their applications by 2025-12-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH PAR-25-218 - Research Infrastructure Development for Interdisciplinary Aging Studies (R61/R33 - Clinical Trial Optional)
What is this funding opportunity?
This is a National Institutes of Health (NIH) grant opportunity titled "Research Infrastructure Development for Interdisciplinary Aging Studies (R61/R33 - Clinical Trial Optional)" under funding opportunity number PAR-25-218. It supports development of new, sustainable research infrastructure to advance interdisciplinary aging science.
What is the main goal of PAR-25-218?
The goal is to build shared, sustainable research infrastructure that helps move aging science forward in areas where progress depends on interdisciplinary partnerships and collaboration.
Is this program meant to fund a single research study?
No. The program is centered on creating shared capacity (infrastructure) rather than funding one standalone research study.
What types of infrastructure can be supported?
Examples include shared platforms, resources, networks, methods, tools, data systems, coordinated teams, or other infrastructure that enables multiple projects to address key aging-related questions at the intersections of different fields.
What does "interdisciplinary aging studies" mean in this context?
It refers to aging-related research questions that sit at the intersections of different scientific or professional fields, where collaboration across disciplines is necessary to make progress.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH Phased Innovation Award mechanism (R61/R33).
How does the R61/R33 phased award structure work?
The award is designed for ideas that need an initial development stage before scaling. The R61 phase supports early development; if milestones and objectives are met, the project can transition to the R33 phase for expansion and full implementation.
How long can the R61 phase last?
Up to two years.
What activities typically happen during the R61 phase?
Applicants would typically build, test, and refine the core components of the proposed infrastructure, demonstrate feasibility, establish partnerships, and meet clearly defined milestones showing the infrastructure works as intended.
How long can the R33 phase last?
Up to three additional years.
What is the purpose of the R33 phase?
The R33 phase supports broader rollout and growth in reach and use, strengthening the infrastructure so it can support multiple interdisciplinary aging projects over time.
Is transition from R61 to R33 automatic?
No. Transition is expected only if the R61 phase meets its objectives and milestones. The specific transition criteria should be confirmed in the full NOFO and related NIH guidance.
What does "sustainability" mean for this program?
Sustainability means the infrastructure should be designed to persist and remain useful beyond the grant period, rather than being a short-lived resource tied to one project team.
Are clinical trials required?
No. Clinical trials are optional.
Can a clinical trial be included?
Yes. Applicants may include a clinical trial component if it is appropriate for developing or validating the proposed infrastructure.
What is the activity category and program type?
The activity category is Health, and the opportunity is classified as a discretionary grant program.
What are the CFDA numbers associated with this opportunity?
The CFDA numbers listed are 93.313 and 93.866.
When is the application closing date?
The listed application closing date is 2025-12-02.
When was this opportunity created?
The opportunity was created on 2024-11-07.
Is there a stated award ceiling or expected number of awards?
The provided information does not include a specific award ceiling or the expected number of awards. Applicants would need to consult the full NOFO and NIH budget guidance for details.
Who is eligible to apply?
Eligibility is broad for domestic U.S. organizations and governmental entities, including many government, education, nonprofit, and for-profit organization types, as well as small businesses.
Which government entities are eligible applicants?
Eligible government applicants include state governments, county governments, city or township governments, special district governments, and eligible federal agencies.
Which education organizations are eligible applicants?
Eligible education organizations include independent school districts, public and state-controlled institutions of higher education, and private institutions of higher education. The NOFO also highlights Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, and TCCUs.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations with or without 501(c)(3) status (outside of higher education) are eligible.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are eligible, and small businesses are also eligible.
Are tribal entities eligible to apply?
Yes. Eligible applicants include Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized governments). The NOFO also highlights Indian/Native American tribal governments that are not federally recognized as an eligible category.
Are housing authorities eligible to apply?
Yes. Public housing authorities and Indian housing authorities are included as eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. The NOFO explicitly highlights faith-based or community-based organizations as eligible.
Are regional organizations eligible?
Yes. The NOFO explicitly highlights regional organizations as eligible.
Are U.S. territories or possessions eligible?
Yes. The NOFO explicitly highlights U.S. territories or possessions as eligible.
Can a foreign (non-U.S.) organization apply as the main applicant?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization.
Can a non-U.S. component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply.
Are foreign collaborations allowed at all?
Yes, but only in a limited way. "Foreign components" are allowed as defined by the NIH Grants Policy Statement, meaning a U.S.-based applicant can include allowable foreign activities or collaborations when they meet NIH policy requirements and are justified as necessary for the project.
What should applicants do to confirm allowable budgets, milestones, and transition criteria?
The provided information notes that applicants should consult the full NOFO and NIH budget guidance for details on allowable budgets, milestones, and R61-to-R33 transition criteria.
What kind of project teams is this program aimed at?
This program is aimed at teams that can bring together multiple disciplines to create enabling infrastructure for aging research, with a clear development plan for the R61 phase, a credible scaling plan for the R33 phase, and a realistic sustainability strategy.
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