Naval Medical Research Center: Austere Environment Consortium for Enhanced Sepsis Outcomes (ACESO) Award | N62645 PA 19 1

Opportunity Information: Apply for N62645 PA 19 1

The Naval Medical Research Center: Austere Environment Consortium for Enhanced Sepsis Outcomes (ACESO) Award is a Department of the Navy research funding opportunity aimed at continuing an established, high-performing program focused on severe sepsis in austere and resource-limited environments. The central purpose is to improve how severe sepsis is prevented, recognized early, diagnosed accurately, and treated effectively when medical resources, staffing, and infrastructure are constrained. Rather than supporting isolated projects, the opportunity is structured around maintaining and advancing a coordinated consortium model so that multiple disciplines can work together toward practical, deployable solutions.

This opportunity is sponsored by the Department of Defense under the Naval Medical Logistics Command, with the Bureau of Medicine and Surgery (BUMED) expressing specific interest in sustaining the Naval Medical Research Center (NMRC) effort. The consortium itself is explicitly named the Austere Environments Consortium for Enhanced Sepsis Outcomes (ACESO). Its role is to generate research knowledge and data that can be translated quickly into real-world improvements in sepsis outcomes, particularly in settings where conventional intensive care capabilities may not be available. The focus on translation is a defining feature: the program is not only about understanding sepsis biology, but also about producing insights, tools, and approaches that can realistically be used in the field or in low-resource clinical contexts.

The research approach envisioned is inherently interdisciplinary. The announcement highlights the need for an established group of investigators with complementary expertise spanning infectious disease, critical care medicine, systems biology, global health, and other relevant scientific or operational areas. The intent is to support coordinated research efforts that benefit from shared strategy, shared data generation, and integrated planning, rather than fragmented, independent studies. In practical terms, this implies a program-level effort where different lines of investigation inform one another, accelerating progress toward better detection methods, better clinical decision-making, and better treatment pathways suited to austere conditions.

From an administrative and funding standpoint, the award uses a cooperative agreement mechanism, which typically indicates substantial involvement by the government partner during program execution compared with a traditional grant. The opportunity is classified as discretionary and falls under the Science and Technology and other Research and Development activity category, with CFDA number 12.340. Eligibility is listed as unrestricted, meaning applications are open to any type of entity, subject to any additional eligibility details that may be provided in the full announcement text. The opportunity anticipated making a single award, with an award ceiling of $52,100,000, signaling an expectation of a large, consortium-scale program rather than a small set of discrete awards. The funding opportunity number is N62645 PA 19 1, it was created on July 5, 2019, and the original closing date was August 5, 2019.

Overall, ACESO is positioned as a continuation and expansion of a proven NMRC consortium effort, with the clear operational goal of reducing death and complications from severe sepsis in settings where patients may be far from advanced hospitals, diagnostic labs, or robust supply chains. The program emphasizes actionable outcomes: improving prevention strategies, speeding recognition and diagnosis, and tailoring treatment approaches so they can succeed under austere constraints, ultimately improving survival and recovery where the burden and risk of severe infection can be especially high.

• The Department of Defense, NAVAL MEDICAL LOGISTICS COMMAND in the science and technology and other research and development sector is offering a public funding opportunity titled "Naval Medical Research Center: Austere Environment Consortium for Enhanced Sepsis Outcomes (ACESO) Award" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.340.
• This funding opportunity was created on Jul 05, 2019.
• Applicants must submit their applications by Aug 05, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $52,100,000.00 in funding.
• The number of recipients for this funding is limited to 1 candidate(s).
• Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.

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